Biosketch Prof Jan De Waele is a surgical intensivist at the department of Critical Care Medicine of the Ghent University Hospital, full professor of Medicine at Ghent University and Senior Clinical Investigator with the Research Foundation Flanders, Belgium. His research activities currently deal with optimizing antibiotic therapy in severely ill infected patients to improve outcome and combat resistance development, with specific interest in PK/PD, therapeutic drug monitoring of antibiotics as well as antimicrobial stewardship. Clinical interests also include abdominal infections, source control and sepsis management. Prof De Waele has experience in organizing clinical studies and is involved in many national and international studies and guideline committees. He is the Chief Investigator of the international, ESICM-endorsed DIANA (2018) and UNITE COVID (2020) studies. He is the past chairman of the ESICM Research Committee (2018-2021), and the 2022-2024 ESICM President-Elect.