Dados do Trabalho

Título

Microbiological profile in Patients with SARS-Cov-2 in Intensive Care Units (ICU) in Brazil: A cross-section

Objetivo

In Brazil, the multidrug-resistant bacteria profile is not well-known among patients with SARS-CoV-2. We aim to evaluate the microbiological profile of SARS-CoV-2 patients in ICU.

Métodos

This is a multicenter prospective study (IMPACTO-MR platform) with data from adult patients from 51 Brazilian ICU coleted in 2021. Frequency of WHO global priority pathogens, such as third-generation cephalosporin-resistant Enterobacteriales (3GCR), carbapenem-resistant Enterobacteriales (CRE), carbapenem-resistant P. aeruginosa (CRPA), carbapenem-resistant A. baumannii (CRAB), methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium (VRE), in patients with SARS-Cov-2 (at least two days of ICU) were evaluated.

Resultados

Data from 1,298 patients corresponding to 1,247 isolates of bacteria of interest were obtained. Of these, 542 (43.5%) were WHO priority pathogens, which 50.9% CRE, 25.3% CRAB, 17.0% CRPA, 5.5% MRSA, and 1.3% were VRE. WHO priority pathogens were more frequently recovered from SARS-Cov-2 patients than from non-SARS-Cov-2 (47.3% vs 42.0%; RR 1.11, 95% CI 1.01–1.21, p=0.03). Among CRE species, K. pneumoniae complex was more frequent in SARS-Cov-2 patients (RR, 1.19 95% CI, 1.01-1.40, p=0,04). In SARS-Cov-2 patients, the median ICU time to acquire a bacteria with a WHO resistance profile was longer than the median ICU time to acquire a bacteria without the WHO resistance profile (13 vs 8 days; p<0.001).

Conclusão

Our data reveal the WHO priority pathogens were more frequent in SARS-Cov-2 patients, probably increasing the morbidity and ICU time of those patients.