Dados do Trabalho

Título

Relationship between thrombotic events and demographic, clinical, and lifestyle variables in Brazilian adults with CNS malignant neoplasm: findings from the TROMBOGLIO Study

Objetivo

To investigate the association between to occurrence of thrombotic events and demographic, clinical, and lifestyle variables in adults with CNS malignant neoplasm from both sexes diagnosed between early 2021 and August 2023.

Métodos

We conducted a multicenter cohort study with 200 participants. Based on medical records data, we analyzed the association between having a thrombotic event and patient-related variables through Chi-square, and Mann-Whitney. Relative risk (RR) was employed as a measure of effect.

Resultados

Our sample predominantly consisted of middle-aged men (n=121; 60.5%). During the 2-year follow-up, 20 (10%) thrombotic events occurred. Patients with a history of previous deep vein thrombosis (DVT) had more events compared to those without a history of DVT (70 vs 7.1%; p<0.001; RR=3.10). Patients with grade 3 and 4 tumors and non-mutant IDH showed a higher proportion of thrombotic events compared to other patients (p>0.050). Patients who used anticoagulants and chemotherapy presented RR=1.23 (95%CI 1.1–1.4) and RR=1.12 (95%CI 1.0–1.2). Nearly one-fifth of the patients died (18.9%). The follow-up period until the occurrence of a thrombotic event was 4.1 months (1-18 months). The median follow-up period between the occurrence of a thrombotic event and the patient’s final status was 2.8 months (1 day to 9 months) and 6.6 months (1 day to 16 months) for patients who died and those who survived (p>0.050).

Conclusão

History of DVT and undergoing radiotherapy and chemotherapy were the primary factors associated with thrombotic events in patients with CNS malignant neoplasm.