Dados do Trabalho

Título

Impact of COVID-19 on outcomes in patients infected by Acinetobacter baumanii

Objetivo

Severe infection caused by multidrug-resistant pathogens are associated with high mortality in critically ill patients. Acinetobacter baumannii (Ab) is one of the most prevalent, being associated with high mortality rates1,2. The aim of our study was describe the relationship between COVID-19 with Ab infection and their outcome.

Métodos

This is a retrospective analysis of patients admitted to the 59 ICU beds of our hospital, between February 2020 and December 2022. Patients infected by Ab were identified through the results of culture of blood, respiratory secretions, or urine. COVID-19 was confirmed by PCR. Data collected for analysis were age, gender, COVID-19 infection, SAPS3 at admission, SOFA at day 1, 3 and 7, length of mechanical ventilation (LMV), length of stay (LOS) and, mortality in ICU and hospital. Statistical analysis was undertaken using descriptive statistics, Pearson’s chi-square and Wilcoxon/Kruskal-Wallis tests.

Resultados

Two hundred and thirteen patients with infection were included in the analysis, of whom COVID-19 test was positive (P) in 109 (51,6%) and negative (N) in 102 (48,4%). Demographic, SAPS 3 and SOFA scores, LMV, LOS and mortality are in the table

Conclusão

COVID-19 P despite at ICU admission presented with less disease severity and organ dysfunction in the first 7 days, had a higher ICU mortality than COVID-19 N. Nonetheless, patients with Ab without COVID had a high hospital mortality rate similar to COVID P. These findings suggests that factors related to COVID-19 could be associated to worst outcome during ICU hospitalization.