Dados do Trabalho

Título

Impact of Prolonged Mechanical Ventilation on Mobility Outcomes: A Single-Center Retrospective Study

Objetivo

To assess the impact of prolonged mechanical ventilation (MV) on mobility outcomes in patients with acute respiratory distress syndrome (ARDS).

Métodos

A single-center retrospective study was conducted, including mechanically ventilated adult patients with ARDS due to COVID-19, admitted to the ICU of a private tertiary hospital (CAAE: 30797520.6.0000.0071). Patients were categorized into prolonged MV (≥ 21 days) and non-prolonged MV (< 21 days).

Resultados

A total of 370 patients were included. Patients who required prolonged MV (29.5%) presented median [IQR] age of 68 [58–75.5] years, were more often male [n=83 (76.1%)], and 68 (62.4%) were classified as pre-frail status according to the modified frailty score. The severity of illness measured by the Simplified Acute Physiology III was higher for the prolonged MV group (58 [52–64] vs. 53 [47–60], respectively; P <0.001). The mobility status measured by the Perme Score at ICU discharge (0 [0–10] vs. 13 [2–23], respectively; P <0.001) and the rate of improved Perme Mobility Index (30.3% vs. 57.1%, P <0.001) was significantly lower in the prolonged MV patients. Despite a higher incidence of sitting on the edge of the bed (23.9% vs. 13.4%, P <0.001), the rate of standing and walking was significantly lower in the prolonged MV patients [22 (20.2%) vs. 116 (44.4%); P <0.001 and 11 (10.1%) vs. 68 (26.1%); P <0.001], respectively.

Conclusão

Critically ill COVID-19 patients with ARDS requiring prolonged mechanical ventilation exhibited worse mobility outcomes.