Dados do Trabalho

Título

The Venous-Arterial CO2 to Arterial-Venous O2 Ratio as a predictor of vasopressor need in septic patients admitted to Intensive Care Units.

Objetivo

To assess whether the venous-arterial CO2 to arterial-venous O2 ratio is a predictor of vasopressor therapy precision in septic patients admitted to Intensive Care Units (ICU).

Métodos

Multicentric prospective cohort study conducted in two hospitals – one in Brazil and the other in Italy – that included adult patients admitted to the ICU. On admission, we calculated the venous-arterial CO2 to arterial-venous O2 ratio using data from arterial and central venous blood gases, together with hemoglobin. We also recorded if the patients, during ICU stay, need vasopressor therapy in any point, using the dichotomous outcome comparison vasopressor need x hemodynamically stability. Statistical analysis was carried out using descriptive statistics with categorical variables being reported as counts and percentages, and continuous variables as means with standard deviations or medians with interquartile ranges. A multivariate model was constructed to assess whether the venous-arterial CO2 to arterial-venous O2 ratio is associated with vasopressor need.

Resultados

A total of 81 patients were included. Between the included patients, 57 (70%) of patients received the diagnosis of Septic shock. The mean venous-arterial CO2 to arterial-venous O2 ratio was higher in patients that needed vasopressors x patients who remained hemodynamically stable: 1.77 (IQR 1.34-2.43) x 1.49 (IQR 0.73-2.15), p=0.045, respectively.

Conclusão

The Venous-Arterial CO2 to Arterial-Venous O2 Ratio may be a good predictor of vasopressor therapy need in septic patients without shock admitted to ICU.